Safety of Anticoagulant Therapy After Variceal Band Ligation

• Status: Completed
• Trial end date: 2021-07-12
• Target enrollment: 0
• Participant gender: All

Summary

Our study is aimed to clarify the safety of anticoagulant therapy after variceal band ligation for cirrhotic variceal bleeding patients with portal vein thrombosis.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Qilu Hospital of Shandong University
• Collaborators: Jinan Military General Hospital; Liaocheng People's Hospital; Shandong Provincial Hospital
• Treatments: Dalteparin; Heparin; Heparin, Low-Molecular-Weight; Tinzaparin; Warfarin

Criteria

Inclusion Criteria:

• clinical diagnosis of cirrhosis

• Portal hypertension with esophageal variceal bleeding

• diagnosis of PVT by imaging examination

• undergo variceal band ligation

Exclusion Criteria:

• liver cancer or other tumors

• cavernous transformation of portal vein

• creatinine more than 20mg/dL，platelet count lower than 10*10^9/L

• ongoing antithrombotic treatment or have received thrombolytic treatment

• pregnancy or breastfeeding

• Having contraindications for endoscopic therapy

• Severe heart and lung diseases，uncontrolled massive hemorrhage or general infection

• major surgery within 3 months

• primary thrombophilia, Budd-Chiari syndrome

• Having received endoscopic therapy, transjugular intrahepatic portosystemic shunt (TIPS) or liver transplantation before