Safety of Combining Modafinil and Nicotine Replacement Therapy in Treating Nicotine Dependent Adolescents

• Status: Completed
• Trial end date: 2011-12-01
• Target enrollment: 0
• Participant gender: All

Summary

Nicotine is one of the most widely abused substances in the United States. Nicotine replacement therapy (NRT) is currently an effective treatment for nicotine dependence; however, even with NRT most people fail at quitting smoking after their first attempt. Modafinil is a promising drug that may be useful in treating nicotine dependent individuals. The purpose of this study is to evaluate the safety of the combination of modafinil and NRT in treating nicotine dependent adolescent smokers.

• Phase: Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Catherine Martin, MD; University of Kentucky
• Collaborator: National Institute on Drug Abuse (NIDA)
• Treatments: Armodafinil; Modafinil; Nicotine

Criteria

Inclusion Criteria:

• Smokes 10 or more cigarettes per day

Exclusion Criteria:

• Current use of any medication for a psychiatric disorder

• Positive drug screen test

• Uses smokeless tobacco