Safety of Continuing Metformin in Diabetic Patients With Normal Kidney Function Receiving Contrast Media

• Status: Completed
• Trial end date: 2014-02-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine whether metformin causes lactic acidosis in diabetic patients with preserved kidney function, undergoing coronary angiography or angioplasty with new contrast media.

In other words is it necessary to discontinue metformin before these procedures, even when Iodixanol is used as contrast media, which is isosmolar agent and much more safer than urografin which was the main agent in the previous studies that were the base of present guidelines?

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Shahid Beheshti University of Medical Sciences
• Treatments: Metformin

Criteria

Inclusion Criteria:

• Diabetic patients receiving metformin who were scheduled for:

• coronary angiography

• coronary angioplasty

Exclusion Criteria:

• Patients who had contraindication for metformin administration, such as:

• decompensated heart failure

• severe liver disease

• severe hypoxemia

• GFR<60 mL/min per 1.73 m2