Safety of Tranexamic Acid in Reducing Bleeding in Adults Undergoing Spinal Surgery
Status:
Completed
Trial end date:
2007-05-01
Target enrollment:
Participant gender:
Summary
Spinal fusion surgery can be associated with significant blood loss requiring allogeneic
blood transfusion. Tranexamic acid is a synthetic amino acid with antifibrinolytic action
that has been shown to reduce perioperative blood loss in patients undergoing cardiopulmonary
bypass for cardiac bypass surgery, knee replacement and liver transplantation surgeries. The
efficacy of antifibrinolytics for reduction of blood loss in major spine surgery has not been
well studied in adult patients. The objective of this study is to determine the efficacy of
tranexamic acid in reducing perioperative blood loss and blood transfusion in adults
undergoing elective spinal fusion in a larger, multi-centered, randomized, double-blinded,
placebo controlled trial.