Saline Lavage X Saline Lavage and Osteonil® Mini in Rizarthritis
Status:
Unknown status
Trial end date:
2019-08-30
Target enrollment:
Participant gender:
Summary
Although a common problem, hand osteoarthritis (HOA) is less studied than knee and hip. In
the age group of 71-100 years, the prevalence of symptomatic HOA reaches 26% of women and 13%
of men. These patients lose hand strength and have difficulty with day-to-day manual
activities. The main joints involved are the proximal and distal interphalangeals and the
carpometacarpal joint of the thumb. In the educational Project PARQVE, the prevalence of HOA
was 23.7% at inclusion in the program, and 47.4% after one year, with loss of grip strength.
There is controversy over the effect of viscosupplementation in the treatment of
rhizarthritis when considering pain. However, strength is a very important function parameter
that must be evaluated for function and quality of life maintenance. Concerned about the
importance of maintaining strength and function in our program (PARQVE), we have added
specific exercises tom improve hand strength and range of motion. Trying to optimize the
treatment and confronting questions about the effect of the joint wash, called placebo in the
comparative studies with corticosteroid and/or hyaluronic acid injection, we did a work where
all the patients will be washed with physiological saline solution but a group, after
emptying, will receive 1mL of hyaluronic acid with mannitol.
PURPOSE: To compare isolated lavage with lavage followed by injection of hyaluronic acid with
mannitol into carpometacarpal osteoarthritis joint of the thumb.
METHODS: Forty joints of patients with multiple osteoarthritis (rhizoarthritis, including)
and comorbidities (two or more of: overweight or obesity, hyperglycemia, dyslipidemia,
hyperuricemia, hypertension) will be allocated into two groups: Lavage (LS) and Lavage and
Injection Hilauronic acid (LO). Both groups will undergo joint lavage with saline solution.
The LO group will receive the 20 mg / mL hilauronic acid injection with 5mg mannitol. Both
groups will be guided in the clinical treatment of osteoarthritis and metabolic syndrome and
will be given daily exercises for the hands. They will be evaluated with the quick DASH
questionnaire, Sollerman Test and by measuring the palmar, lateral and pulp-pulp grip
strength, in addition to measuring the ROM and VAS pain moments immediately prior to the
procedure, one, three and six months after the articular procedure.