Salivary Cortisol Measurement in Corticotrope Deficiency Substitution With Hydrocortisone.

• Status: Completed
• Trial end date: 2021-04-30
• Target enrollment: 0
• Participant gender: All

Summary

Patients with adrenal insufficiency are most often overdosed with hydrocortisone. To date, there is no reliable marker that can reflect the quality of hydrocortisone substitution. Salivary cortisol is a good reflection of free plasmatic cortisol. However, salivary contamination with the oral intake of hydrocortisone has been described.

The aims of the study are to:

• evaluate the frequency of salivary contamination by hydrocortisone taken in tablet form and determine its risk factors.

• evaluate the quality of hydrocortisone substitution in patients with corticotrope deficiency.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University Tunis El Manar
• Treatments: Hydrocortisone

Criteria

Inclusion Criteria:

-patients with corticotrope deficiency treated with hydrocortisone for at least one year.

Exclusion Criteria:

• alcoholism,

• morbid obesity,

• long standing or uncontrolled diabetes mellitus,

• uncontrolled hypothyroidism,

• depression,

• chronic or acute inflammatory or infectious disease,

• neoplasia,

• renal or hepatic disease,

• malabsorption,

• pregnant or breast-feeding women,

• treatment with corticosteroids other than hydrocortisone, enzyme inducers or oestrogens.