Salivary Cortisol Measurement in Corticotrope Deficiency Substitution With Hydrocortisone.
Status:
Completed
Trial end date:
2021-04-30
Target enrollment:
Participant gender:
Summary
Patients with adrenal insufficiency are most often overdosed with hydrocortisone. To date,
there is no reliable marker that can reflect the quality of hydrocortisone substitution.
Salivary cortisol is a good reflection of free plasmatic cortisol. However, salivary
contamination with the oral intake of hydrocortisone has been described.
The aims of the study are to:
- evaluate the frequency of salivary contamination by hydrocortisone taken in tablet form
and determine its risk factors.
- evaluate the quality of hydrocortisone substitution in patients with corticotrope
deficiency.