Salivary Epidermal Growth Factor (EGF) Concentration Before and After Treatment of Reflux Laryngitis
Status:
Completed
Trial end date:
2011-07-01
Target enrollment:
Participant gender:
Summary
- Saliva plays a key role in the homeostasis of the digestive tract
- The reflux of gastroesophageal contents may cause damage to the esophageal, laryngeal
and pharyngeal mucosas
- There seems to be no correlation between the severity of reflux episodes and the
intensity of inflammatory changes, suggesting individual protective mechanisms to
refluxate exposure
- Inorganic and Organic Salivary changes have been associated to Gastroesophageal Reflux
Disease (GERD) and its supraesophageal manifestations, especially reflux laryngitis
(Laryngopharyngeal Reflux- LPR)
- Decreased salivary Epidermal Growth factor (EGF) concentrations have been found in
patients with GERD and LPR, but it is unclear if these are primary or secondary to the
disease.
- Hypothesis: The decreased salivary EGF concentrations in patients with reflux laryngitis
is primary and therefore would not change after treatment and control of the disease
Details
Lead Sponsor:
Faculdade de Ciências Médicas da Santa Casa de São Paulo