Salt Loading and Thiazide Intervention Study

• Status: Completed
• Trial end date: 2013-03-01
• Target enrollment: 0
• Participant gender: All

Summary

The investigators of this study propose to examine the relationships between STK39 (Serine Threonine Kinase 39) genotypes and responses to salt loading and to thiazide diuretics, hydrochlorothiazide. The investigators hypothesize that STK39 genotypes will be associated with the outcome of both interventions and can contribute to personalized care for hypertension.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Maryland; University of Maryland, Baltimore
• Collaborator: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
• Treatments: Diuretics; Hydrochlorothiazide

Criteria

Inclusion Criteria:

• Old Order Amish

• Age 18 to 65

• Have systolic blood pressure between 120 and 160 and diastolic blood pressure between 80 and 100

Exclusion Criteria:

• History of myocardial infarction, stroke, congestive heart failure, liver disease

• Known cause of secondary hypertension

• Diabetes or Fasting glucose > 100 mg/dL

• Women who are pregnant, on oral contraceptives, or menstruating

• Used hydrochlorothiazide (HCTZ) in the last 8 weeks or known allergy to HCTZ

• Taking non-steroidal anti-inflammatory drugs

• Estimated glomerular filtration rate < 80 mL/m

• Intention to alter dietary habit during the study

• Abuse of alcohol or drug