Salvage: Postconditioning With Adenosine for STEMI

• Status: Unknown status
• Trial end date: 1969-12-31
• Target enrollment: 0
• Participant gender: All

Summary

Investigate the effect of selective intracoronary administration of adenosine on myocardial salvage and microvascular integrity in the setting of acute myocardial infarction.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University Hospital, Gasthuisberg
• Treatments: Adenosine

Criteria

Inclusion Criteria:

• Myocardial infarction of less than 12 hours duration with symptoms lasting at least 20 minutes.

• ECG-criteria: ST-segment elevation of > 0.1 mV in 2 or more limb leads or > 0.2 mV in 2 or more contiguous precordial leads or presumed new left bundle branch block.

• Written informed consent prior to inclusion in the study. If this is not possible, verbal informed consent from the patient or written assent of a legally acceptable representative should be obtained, to be followed by written informed consent by the patient at the earliest subsequent opportunity.

• Adequate vascular access seems possible (femoral pulsation palpable).

Exclusion Criteria:

• Contra-indication to heparin, LMWH, clopidogrel.

• Anticipated difficulty with vascular access.

• Cardiogenic shock.

• Inability to give informed consent (or assent).

• High grade atrioventricular block; severe asthma; treatment with theophylline, glibenclamide (Diamicron) or dipyridamole.

• Prior CABG.

• Participation in an investigational drug or device study within the past 30 days.