Salvage Therapy With Amprenavir, Lopinavir and Ritonavir in HIV-Infected Patients in Virological Failure.
Status:
Completed
Trial end date:
2002-02-01
Target enrollment:
Participant gender:
Summary
HIV infected patients are treated with highly active antiretroviral therapy (HAART). Side
effects and the great number of pills reduces adherence to the treatment, and induces
therapeutic failure. In order to maintain efficacy of HAART, new combination is evaluated.
The aim of the study is to compare the antiviral efficacy of this salvage therapy combining
lopinavir and amprenavir with 200 mg/d or 400 mg/d ritonavir, together with nucleoside
reverse transcriptase inhibitors, over a 26-week period in HIV-infected patients in whom
multiple antiretroviral regimens had failed.
Phase:
Phase 2
Details
Lead Sponsor:
French National Agency for Research on AIDS and Viral Hepatitis