Sanctura Muscarinic Receptor Antagonist Resists Transport (SMART) Trial
Status:
Completed
Trial end date:
2009-08-01
Target enrollment:
Participant gender:
Summary
This study evaluates the penetration through the blood-brain-barrier of trospium chloride at
plasma steady state (Day 10) in elderly subjects with overactive bladder symptoms. Trospium
levels in cerebrospinal fluid (CSF) and peak and trough plasma levels will be measured.
Baseline and day 10 post-dose neurocognitive testing will be compared using a reliable change
index to assess if any study subject shows evidence of a clinically and statistically
significant change in memory.