Scalp Infiltration With Dexamethasone Plus Ropivacaine for Post-craniotomy Pain
Status:
Not yet recruiting
Trial end date:
2022-11-01
Target enrollment:
Participant gender:
Summary
According to recent studies, patients following craniotomy suffer more than minimal pain;
two-thirds of patients experienced moderate to severe pain. Postoperative pain most often
occurs within 48 hours after surgery. Local infiltration of anesthesia is the most simple and
effective analgesia. However, the analgesic effect only lasts for a short-time after surgery,
and it cannot adequately meet the needs of postoperative analgesia after craniotomy. Several
studies have shown that the mixture of dexamethasone with local anesthetics could reduce the
postoperative pain scores better than local anesthetics alone. Lipid microsphere is a
relatively new drug delivery system. It is an artificial lipid emulsion. Studies have shown
that dexamethasone lipid microsphere have stronger anti-inflammatory effect than
dexamethasone. Therefore, the investigators hypothesize that the pre-emptive scalp
infiltration with dexamethasone or dexamethasone lipid microsphere plus ropivacaine could
achieve superior postoperative pain-relief compared to ropivacaine alone; dexamethasone lipid
microsphere plus ropivacaine could achieve superior postoperative pain-relief compared to
dexamethasone plus ropivacaine for patients undergoing craniotomy.