Scheduled Ketorolac Administration After Cesarean Section and Its Effect on Opioid Consumption: a Randomized Control Trial

• Status: Recruiting
• Trial end date: 2022-06-01
• Target enrollment: 0
• Participant gender: Female

Summary

This study evaluates how a protocol of scheduled non-narcotic anesthetic used in the immediate post-operative period affects the average patient pain scale scores and the amount of oral narcotic medication administered. The objective of the study is to identify a post-operative pain control regimen that can decrease the amount of oral narcotic medications administered in the post-operative period.

The primary outcome will be the amount of morphine milligram equivalents (MME) used in each group. Secondary outcomes will include pain scores, postoperative complete blood count, and post-operative satisfaction with care received during admission.

• Phase: Phase 3
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Tufts Medical Center
• Treatments: Ketorolac; Ketorolac Tromethamine

Criteria

Inclusion Criteria:

• Women presenting for care at Tufts Medical Center as an outpatient in obstetrics clinic or on Labor and Delivery.

• The subject must have had a cesarean section for any indication at Tufts Medical Center to be randomized to the study

• The subject is willing to have a phone call follow up conversation 2 weeks after their surgery.

Exclusion Criteria:

• Patients with allergy to ketorolac, NSAIDS or aspirin

• Patients with peptic ulcer disease, preexisting kidney or liver disease.

• Duramorph is not used as the anesthetic for the spinal/epidural during the cesarean section.

• Patient is hemodynamically unstable due to hemorrhage.

• Patient requires therapeutic anticoagulation in the post-operative period

• Patients with peripartum cardiomyopathy

• Provider decision to exclude patient.

• A study subject may participate in another research study while participating in this research study.