Schistosome and Intestinal Worm Infections and Malaria Morbidity Among School and Pre-school Children in, Tanzania
Status:
Completed
Trial end date:
2011-01-01
Target enrollment:
Participant gender:
Summary
The proposed study has as the main objective to investigate the effect of schistosome and STH
infections and the effect of an anthelminthic intervention on P. falciparum malaria, related
anaemia and malaria antibody responses among school and pre-school children in Mwanza,
Tanzania. The study will include a cross-sectional baseline survey followed by an
anthelminthic intervention trial of two years duration. At baseline, prevalence and intensity
of malaria, schistosome and STH infections and the prevalence of anaemia will be determined
by examination of blood, faecal and urine samples. Spleen and liver size and consistency will
be determined by palpation. P. falciparum specific antibodies will be determined by ELISA.
All children will be treated with a single dose of praziquantel 40mg/kg and albendazole
400mg. Children selected to participate in the intervention trial will be randomized into two
groups, an intervention group of 258 children which will be followed up with albendazole
400mg and praziquantel 40mg/kg at three months interval and a control group of 258 children
which will be followed up with praziquantel 40mg/kg and albendazole 400mg once a year in
accordance with the National Schistosomiasis and Soil-transmitted Helminths Control
Programme. At 12 months and 24 months follow-up, all examinations conducted at baseline
survey will be repeated.
Phase:
N/A
Details
Lead Sponsor:
DBL -Institute for Health Research and Development