Screening for Latent Tuberculosis Infection (LTBI) in US Army Recruits
Status:
Active, not recruiting
Trial end date:
2022-08-01
Target enrollment:
Participant gender:
Summary
The overall objective of this study is to assess the feasibility and potential impact of
using a targeted testing approach and 2 interferon-gamma release assays (IGRA) to screen for
latent tuberculosis (TB) infection (LTBI) among military recruits. The current policy of
universal application of the Mantoux tuberculin skin test (TST) to screen for LTBI may result
in many TST reactions among recruits who are at low risk for LTBI. The central hypothesis is
that targeted testing by use of the questionnaire will reduce unnecessary testing of low-risk
recruits without affecting the identification of higher-risk recruits. The secondary
hypothesis is that many discordant results between the TST and IGRA may be explained by
cross-reactivity to non-tuberculous mycobacteria (NTM) with the TST.
Phase:
N/A
Details
Lead Sponsor:
Uniformed Services University of the Health Sciences