Screening in Oculopharyngeal Muscular Dystrophy

• Status: Recruiting
• Trial end date: 0000-00-00
• Target enrollment: 50
• Participant gender: Both

Summary

Oculopharyngeal muscular dystrophy (OPMD) is a rare myopathic disease that results in progressive degeneration of the oral and pharyngeal muscular, resulting in severe dysphagia and dysarthria. OPMD is considered a rare disease; therefore, limited research is available on the natural progression of the disease or the utility of biomarkers to identify swallowing impairment. The aim of this study is:

1. To identify accurate, reliable and non-invasive clinical markers of swallowing impairment

2. To determine the discriminate ability of these markers to identify impairments in swallow safety and swallowing efficiency.

• Phase: Phase 0
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Florida
• Treatments: Capsaicin
• Last Updated: 2016-12-14

Criteria

Inclusion Criteria:

• diagnosis of oculopharyngeal muscular dystrophy

• no allergies to barium or capsaicin,

• no tracheotomy or mechanical ventilation

• no significant concurrent respiratory disease (e.g., COPD).

Exclusion Criteria:

• Pregnant Women