Seasonal Intermittent Preventive Treatment With Sulfadoxine-Pyrimethamine in Children in Mali
Status:
Completed
Trial end date:
2004-01-01
Target enrollment:
Participant gender:
Summary
Recent, randomized controlled trials conducted in areas of perennial malaria transmission
have shown that intermittent preventive treatment (IPT) given at the time of vaccination
reduced the incidence of the first episode of malaria and severe anaemia during the first
year of life by more than 50% without there being any rebound in the subsequent year.
However, in countries such as Mali, where malaria is highly seasonal and prevalent in older
children, IPT in infants may not be the optimum way in which to use antimalarial drugs to
prevent malaria. An alternative approach is to give intermittent preventive treatment to
children at risk just during the rainy season. Here we propose (i) to evaluate the impact of
two seasonal IPT (sIPT) with Sulfadoxine-pyrimethamine (SP) given at 8 weeks interval on the
incidence of malaria disease in children of 6 months to 10 years in an area of seasonal
transmission, in Kambila, Mali; (ii) to assess the impact of this strategy on the in vivo
response of P. falciparum to SP; (iii) to assess the potential rebound effect of this
strategy on the subsequent transmission season after the cessation. Children 6 months-10
years in Kambila, Mali will randomized to receive either IPT with SP twice at 8 weeks
interval or no IPT during the transmission season and will followed up for 12 months.
Subjects will be also followed during the subsequent transmission season to assess possible
rebound effect. Clinical malaria cases will be treated with SP and followed for 28 days to
assess the in vivo response during both periods.
Phase:
N/A
Details
Lead Sponsor:
University of Bamako
Collaborator:
World Health Organization
Treatments:
Fanasil, pyrimethamine drug combination Pyrimethamine Sulfadoxine