Second-Line Uterotonics in Postpartum Hemorrhage: A Randomized Clinical Trial

• Status: Recruiting
• Trial end date: 2022-03-01
• Target enrollment: 0
• Participant gender: Female

Summary

The aim of this study is to evaluate in a randomized fashion the comparative efficacy of two second-line medications, methylergonovine and carboprost for treating atonic postpartum hemorrhage (PPH). The investigators hypothesize that administration of methylergonovine will produce superior uterine tone to carboprost in atonic PPH.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Brigham and Women's Hospital
• Treatments: Carboprost; Carboprost tromethamine; Dinoprost; Dinoprost tromethamine; Maleic acid; Methylergonovine

Criteria

Inclusion Criteria:

• pregnant with a fetus >/=24 weeks gestational age

• non-emergent cesarean delivery

• postpartum hemorrhage deemed the result of uterine atony

Exclusion Criteria:

• non-English speaking patients requiring an interpreter

• any hypertensive disorder

• cardiovascular disease

• asthma

• refusal of transfused blood products

• coagulopathy or abnormal coagulation lab values

• hypersensitivity to methylergonovine maleate or 15-methyl prostaglandin