Secondary Prophylaxis After Variceal Bleeding in Non-Responders

• Status: Completed
• Trial end date: 2004-06-01
• Target enrollment: 0
• Participant gender: All

Summary

Controlled and randomized study comparing combined treatment (nadolol and endoscopic ligation) versus nadolol associated with isosorbide mononitrate or prazosin according to hemodynamic response, in the prevention of esofagic verices rebleeding.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
• Treatments: Isosorbide; Isosorbide Dinitrate; Isosorbide-5-mononitrate; Nadolol; Prazosin

Criteria

Inclusion Criteria:

• Any Patient with endoscopically assessed Variceal Bleeding (esofagic and gastric)

• Cirrhosis

• Patient agreement to be included in the study onsentiment signed

Exclusion Criteria:

• Any associated comorbidity with life expectancy lesser than 6 months

• Patient refusement to be included in the study.

• Pregnancy

• Failure to control acute bleeding

• Previous prophylaxis treatment