Sedation Efficacy of Dexmedetomidine Versus Midazolam in Critically Ill Ventilated Children
Status:
Recruiting
Trial end date:
2023-05-01
Target enrollment:
Participant gender:
Summary
There is a significant lack of adequately powered randomized clinical trial (RCT) data to
determine the comparative safety and effectiveness of sedative treatments in pediatric
patients. In many centres the standard of care for sedation in pediatric critical care unit
(PCCU) patients includes the use of benzodiazepines despite the known negative effects of
increased patient agitation and delirium, which can contribute to longer PCCU and hospital
length of stay (LOS). The use of an alternative sedative, dexmedetomidine may reduce negative
effects in this population. As such, the investigators plan to conduct a well designed
comparative RCT to determine the most effective and safest sedative in this vulnerable
population utilizing clinical assessments of sedation levels and delirium instance,
electroencephalography (EEG) analysis and patient important outcomes.