Sedation and Memory Consolidation

• Status: Recruiting
• Trial end date: 2021-10-31
• Target enrollment: 0
• Participant gender: All

Summary

The study of plasticity processes, in particular, memory, is one of the fundamental directions in anesthesiology. To date, there are different views on the impact of sedation and anesthesia on memory. Memory consolidation is one of the most crucial processes that the anesthesiologist is interested in. Memory consolidation is the mechanism of transferring short-term memory to long-term memory. The investigators suppose that propofol or dexmedetomidine sedation disrupts memory consolidation. In addition, the investigators inquired about the impact of sedation on 'working memory'. Therefore, a better understanding of the influence of anesthesia and sedation on basic memory processes will allow the anesthesiologist to balance the choice of the drug and ensure the patient's safety in the intraoperative period.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: I.M. Sechenov First Moscow State Medical University
• Treatments: Dexmedetomidine; Propofol

Criteria

Inclusion Criteria:

• Written informed consent

• Age ≥ 18 and ≤70 years

• Elective trauma surgery (arthroscopy, reconstructive foot surgery) under regional anesthesia (spinal anesthesia) with propofol, dexmedetomidine or without sedation

• Montreal cognitive assessment test ≥ 26

• Patients with American Society of Anesthesiologists (ASA) I-II

Non-inclusion criteria:

• Not written informed consent to participate in the research and/or perform regional blockade

• Age˂18 and ˃70 years

• Allergy to propofol, dexmedetomidine, lidocaine, bupivacaine

• Pregnancy

• Epilepsy anamnesis

• II-III degree atrioventricular block

• Montreal cognitive assessment test ˂ 26

• Patients with American Society of Anesthesiologists (ASA) ˃ II

• Emergency operation

• The presence of psychiatric disorders

• Сancer patients with a life expectancy of less than two years

• Taking anticoagulants, psychotropic drugs

Exclusion Criteria:

• Patient refuse from further participation

• Ineffective spinal anesthesia

• Allergy on anesthesia drugs during perioperative period