Sedation and Pain (The Effect of IV Sedation on Pain Perception)

• Status: Completed
• Trial end date: 2012-01-01
• Target enrollment: 0
• Participant gender: All

Summary

The investigators propose to evaluate the potential effect of sedation on pain perception in two ways, by asking for a participant's pain rating(subjective) and by evaluating a subject's brain activation using fMRI(objective).

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Alabama at Birmingham
• Collaborator: American Society of Regional Anesthesia
• Treatments: Dexmedetomidine; Midazolam; Propofol

Criteria

Inclusion Criteria:

Healthy subjects

• 19 years or older able to follow study instructions

Exclusion Criteria:

• Age less than 19 or greater than 40

• Pregnant female

• Obesity (BMI > or =35)

• Non-English speaking/reading participants

• Sleep apnea

• Pulmonary problems such as moderate or severe bronchial asthma

• Cardiovascular problems such as hypertension

• History of claustrophobia

• Presence of a pacemaker, defibrillator, surgically placed metallic object (e.g., hip replacement)or other implanted device

• Presence of an unremoved bullet or shrapnel in the body

• Presence of a prosthetic that is not removable

• Presence of a hearing aid needed for hearing

• Head girth exceeding that of the head coil used in the magnet

• Extensive metalwork on or in teeth, or irremovable false teeth or bridgework

• Epilepsy

• Chronic analgesic medication

• Excessive tattoos (due to local skin heating with tattoos containing ferromagnetic particles)

• History of surgery for which details are unavailable

• Allery due to study drugs

• History of drug abuse