Sedation for Non-invasive Ventilation in Blunt Chest Trauma

• Status: Enrolling by invitation
• Trial end date: 2022-02-20
• Target enrollment: 0
• Participant gender: All

Summary

Effectiveness of sedation using dexmedetomidine and ketamine to facilitate non-invasive ventilation sessions which improve overall outcome after blunt chest trauma

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Aswan University Hospital
• Treatments: Dexmedetomidine; Ketamine

Criteria

Inclusion Criteria:

All blunt chest trauma patients with:

• More than 3 rib fractures, pulmonary contusion,

• hypoxemia or hypercapnia, or respiratory rate 20/ min despite an optimized intravenous analgesia ( paracetamol 1gm i.v. 6hourly and ketolac 30mg i.v. 8 hourly)

• No indication of mechanical ventilation

Exclusion Criteria:

• Patients < 18 years old,

• admitted under mechanical ventilation

• admitted more than 24 h after trauma or from another hospital,

• patients with less than 3 ribs fractures

• patients did not receive CT-scan

• Patients in whom alpha-2 agonists or ketamine are contraindicated

• Patients who will require an intubation during the study period for a life-threatening condition or emergency surgery or agitation as defined by a Richmond Agitation Sedation Scale (RASS) score higher than +2 will also excluded.