Selection of Antibiotic Resistance by Azithromycin and Clarithromycin in the Oral Flora

• Status: Completed
• Trial end date: 2003-10-01
• Target enrollment: 0
• Participant gender: All

Summary

Resistance to antibiotics is a major public-health problem and studies linking antibiotic use and resistance have shown an association not a causal effect. Utilizing the newer macrolides, azithromycin and clarithromycin that are commonly prescribed for respiratory infections, we investigated the direct impact of antibiotic exposure on resistance at the individual level.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Universiteit Antwerpen
• Collaborator: Abbott
• Treatments: Anti-Bacterial Agents; Azithromycin; Clarithromycin

Criteria

Inclusion Criteria:

• healthy adults (≥ 18 years of age)

• non-pregnant

• free of any respiratory tract infection

• not having been administered any antibiotic at least in the past three months

Exclusion Criteria:

• <18 years of age

• pregnant

• having a respiratory tract infection

• having been administered any antibiotic at least in the past three months