Selective Serotonin Reuptake Inhibitors, Fluoxetine Versus the Standard Oral Desmopressin for Management of Mono-symptomatic Nocturnal Enuresis.

• Status: Active, not recruiting
• Trial end date: 2024-03-01
• Target enrollment: 0
• Participant gender: All

Summary

To determine whether there is a role for the selective serotonin reuptake inhibitors fluoxetine versus desmopressin in the treatment of nocturnal enuresis in children who have not responded to standard nonpharmacological urotherapy, and whether there are side effects involved.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Fayoum University Hospital
• Treatments: Deamino Arginine Vasopressin; Fluoxetine

Criteria

Inclusion Criteria:

1. Age ≥ 7 years

2. Severe enuresis with at least (50%) seven wet nights out of 14

3. Failed treatment

4. The enuresis alarm was either ineffective or considered impractical due to the family circumstances.

Exclusion Criteria:

1. Underlying renal, urologic, neurologic, endocrinologic, or cardiac conditions

2. Patients with psychiatric disorders and behavioral disorders including depression, attention-deficit/hyperactivity disorder.

3. Untreated constipation

4. Contraindications to fluoxetine or desmopressin treatment