Selenium Sulfide, Ketoconazole and Ciclopirox Shampoo as Additional Treatments for Tinea Capitis (Scalp Ringworm)
Status:
Completed
Trial end date:
2008-04-01
Target enrollment:
Participant gender:
Summary
Antifungal shampoos have been used as supplements to oral griseofulvin to help eradicate
tinea capitis (also known as ringworm of the scalp) more quickly. While selenium sulfide
shampoo has been the gold standard, its strong odor and its drying effect on the scalp
discourage many patients from using it. Meanwhile, no other antifungal shampoo has been
rigorously evaluated for efficacy. Therefore, while physicians are prescribing griseofulvin
accompanied by any of a number of antifungal shampoos for tinea capitis, it is not known
which antifungal shampoos (excluding selenium sulfide) actually significantly reduce time to
cure, nor which do so the fastest.
Scalp ringworm can also re-occur in the same child. To date, no studies have been done to
find out whether or not the use of antifungal shampoos can prevent the recurrence of scalp
ringworm.
In this study, children ages 1-12 years old, who have clinically diagnosed tinea capitis,
will all be prescribed oral griseofulvin for 8 weeks. In addition, they will be randomly
assigned to use either selenium sulfide shampoo, ketoconazole shampoo, ciclopirox shampoo, or
baby shampoo twice a week for 8 weeks. After 8 weeks, griseofulvin will be stopped. All
patients will continue using the same assigned shampoo twice weekly for 24 weeks, while
continuing to return to clinic every 4 weeks for scalp evaluation.
Phase:
N/A
Details
Lead Sponsor:
Chen, Catherine, M.D.
Collaborators:
Eastern Virginia Medical School Hubbard, Thomas W., M.D. Williams, Judith V., M.D.