Selenium and Ischemic Stroke Outcome

• Status: Completed
• Trial end date: 2018-01-01
• Target enrollment: 0
• Participant gender: All

Summary

Selenium is a trace element essential to human health.Selenium protection against cellular damage by oxygen radicals is accomplished through selenoproteins. Ischemic stroke is associated with the generation of oxygen free radicals resulting in a condition of oxidative stress. Supplementing stroke patients with antioxidant nutrients may improve survival.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Mazandaran University of Medical Sciences
• Treatments: Selenium

Criteria

Inclusion Criteria:

1. Accepted ischemic stroke by brain CT or MRI during last 72 h

2. Ischemic stroke in Middle Cerebral Artery territory

3. Volume of stroke at list one third of MCA territory

4. written informed consent.

Exclusion Criteria:

1. Known allergy to selenium

2. Severe renal failure( cr clearance under 50 ml/min or serum cr upper than 2

3. Severe hepatic failure( total bill upper than 2 or ALT/AST 5 time upper than normal limit)

4. Severe neurodegenerative disease such as severe dementia, alzheimer and Parkinson

5. Pregnancy or lactation