Sensorial and Physiological Mechanism-based Assessments of Perioperative Pain

• Status: Suspended
• Trial end date: 2021-12-31
• Target enrollment: 0
• Participant gender: Female

Summary

The overall goal of this proposal is to determine if quantitative sensory testing (QST) assessing pain modulation can be used as a clinical tool to optimize perioperative pain management. The central hypothesis is that the identification of patient's sensory pain profile allows personalizing therapeutic approaches to improve individualized pain management and thus prevents pain chronicity.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Dr. Jean A. Ouellet, MD, FRCSC
• Collaborators: Catherine Ferland; Pablo Ingelmo
• Treatments: Clonidine; Morphine

Criteria

Inclusion Criteria:

• Females* aged between 10 and 21 years old

• Scheduled to undergo anterior or posterior spinal fusion surgery for AIS with instrumentation

• Ability to adequately understand and respond to outcome measures

• No previous major orthopedic surgery

• Any ethnic background

Exclusion Criteria:

• Children with history of allergies to Clonidine or it's excipients in either injection or tablet formulation (see respective monograph)

• Children with history of galactose intolerance

• Children with history of myocardial disease, arrhythmias, cerebrovascular disease, Raynaud's/Thromboangiitis obliterans or chronic renal failure diagnosis based on history and physical

• Children taking anti-hypertensive agents (diuretics, vasodilators, beta-blockers, ace-inhibitors)

• History of depression

• Inability of the child to speak English or French

• Diagnosed with developmental delay that would interfere with understanding the questions being asked (autism, mental retardation)

• Children with major chronic medical conditions (ASA status III or higher)

• Pregnancy excluded by an in hospital testing the night before surgery