Serial Use of Intravenous and Oral Tranexamic Acid in Primary Total Knee Arthroplasty Patients
Status:
Unknown status
Trial end date:
2019-02-01
Target enrollment:
Participant gender:
Summary
The usefulness of tranexamic acid(TXA) to reduce blood loss and transfusion in total knee
replacement arthroplasty(TKRA) has been demonstrated. However, the optimal does, duration of
treatment and route of administration of TXA to reduce blood loss while minimizing adverse
effects remain uncertain. Recently, the serial use of perioperative IV and post-operative
oral TXA has been shown to significantly reduce transfusion rate without increasing
thromboembolic complications compared to placebo. The aim of this study is to 1) determine
the beneficial effect and safety of the serial treatment of IV and oral TXA over IV use alone
and 2) assess the sufficient length of postoperative use of oral TXA in TKRA patients.