Serotonergic Modulation of Cognition, Emotion and Brain Activation in Healthy Volunteers
Status:
Active, not recruiting
Trial end date:
2024-08-30
Target enrollment:
Participant gender:
Summary
The aim of this project is:
- To apply a pharmacological tool of selective serotonin (5-hydroxytryptamine, 5-HT
system) reuptake inhibition in healthy humans. Specifically:
- To investigate how sub-chronic administration of 20 mg of escitalopram affects cognitive
performance ('cold' cognition) and social-emotional functioning ('hot' cognition)
compared with placebo; and
- To investigate how sub-chronic administration of 20 mg of escitalopram affects
functional brain activation during a paradigm of reinforcement learning following drug
administration compared with placebo, and how activation relates to cognitive
performance and social-emotional functioning.