Sertraline Combined With Fluvoxamine in the Treatment of Refractory Obsessive-compulsive Disorder

• Status: Recruiting
• Trial end date: 2024-12-31
• Target enrollment: 0
• Participant gender: All

Summary

To verify that sertraline combined with fluvoxamine is superior to sertraline combined with aripiprazole

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University
• Treatments: Aripiprazole; Fluvoxamine; Sertraline

Criteria

Inclusion Criteria:

• The Diagnostic criteria of OCD in the Diagnostic and Statistical Manual of Mental Disorders 5th edition (DSM-V), as well as the definition of refractory OCD, are as follows: failure to respond to oral treatment with at least two effective doses of antidepressants, including: Fluoxetine (≥20mg/ d), fluvoxamine (≥200mg/d), sertraline (≥150mg/d), and paroxetine (≥ 40mg/d) were all treated for at least 12 weeks. The Yale-Brown compulsive scale (Y-BOCS) score decreased by < 35%.

• The total score of Yale- Brown compulsion scale (Y-BOCS) ≥16 points. (3)age 12 ~ 45 years.

Exclusion Criteria:

• Exclusion of severe organic brain disease;

• Severe physical illness;

• Other mental disorders such as tics, disruptive disorders, eating disorders and autism spectrum disorders;

• Pediatric streptococcal infection causedby autoimmune neuropsychiatric disease (PANDAS);

• Alcohol and drug dependence; Angle-closure glaucoma;

• Suicidal tendencies;

• Previous history of drug allergies related to research;

• Pregnant and lactating women.