Sertraline for the Prevention of Recurrent Postpartum Depression

• Status: Completed
• Trial end date: 2006-08-01
• Target enrollment: 0
• Participant gender: Female

Summary

This study will determine the effectiveness of taking sertraline within 24 hours of giving birth in preventing a recurrence of postpartum depression.

• Phase: Phase 3
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Pittsburgh
• Collaborator: National Institute of Mental Health (NIMH)
• Treatments: Sertraline

Criteria

Inclusion Criteria:

• Pregnant

• Presents by week 36 gestation for first two study visit interviews (interviews may be combined)

• History of DSM-IV Major Depression after the age of 15

• Score no higher than 19 on the 29-item SIGH-ADS at Week 36

• Medically healthy, as determined by a physician

Exclusion criteria

• Current major depression

• Urine screen positive for drugs

• Currently using other therapies for depression

• DSM-IV diagnoses of bipolar 1 or 2 disorder or any psychotic episode

• History of substance abuse within 6 months prior to study entry

• Has not received any obstetrical care

• Use of medications for medical disorders (except for treatment of stable disorders)