Overview
Serum Creatinine Change / Renal Adverse Effect With Use of Non-steroidal Painkillers in Axial Spondyloarthritis Patients
Status:
Completed
Completed
Trial end date:
2016-06-23
2016-06-23
Target enrollment:
0
0
Participant gender:
All
All
Summary
2 Non-steroidal anti-inflammatory drugs (NSAIDs), indomethacin and etoricoxib were prescribed sequentially in Axial Spondyloarthritis patients according to the internationally accepted guidelines to determine serum creatinine change with NSAIDs use.Phase:
Phase 4Accepts Healthy Volunteers?
NoDetails
Lead Sponsor:
Bangabandhu Sheikh Mujib Medical University, Dhaka, BangladeshTreatments:
Etoricoxib
Indomethacin
Criteria
Inclusion Criteria:- SpA (axial) patients according to Assessment of Spondyloarthritis International
Society (ASAS) criteria with BASDAI > 4
Exclusion Criteria:
- Inadequate response to therapeutic dose of indomethacin or etoricoxib, taken for at
least 2 weeks continuously
- Abnormal serum creatinine : serum creatinine >1.3 mg/dl
- Abnormal SGPT: SGPT > 40 U/L
- Hypertension: Systolic blood pressure > 140 mm Hg and/ or diastolic blood pressure >90
mm Hg or on anti-hypertensive drug
- Dyspepsia or active peptic ulcer disease : upper abdominal discomfort or upper
abdominal pain related with food or peptic ulcer disease diagnosed by upper
gastrointestinal endoscopy
- Diabetes mellitus: abnormal random plasma glucose or diagnosed case of diabetes
mellitus
- Ischemic heart disease: history of angina or ECG changes suggestive of ischemic heart
disease
- Active congestive heart failure: pedal edema with tender hepatomegaly with raised JVP
or diastolic dysfunction on echocardiography
- Asthma: diagnosed case of asthma or rhonchi on chest auscultation
- Bleeding problems: having a history of prolonged bleeding
- Pregnancy: missed period followed by positive pregnancy test
- Simultaneous use with certain medications such as warfarin, phenytoin, cyclosporine,
probenecid, lithium, digoxin, ACE inhibitor, thiazide