Serum Thromboxane B2 Assay as a Measure of Platelet Production in Healthy Volunteers Taking Aspirin
Status:
Completed
Trial end date:
2019-09-03
Target enrollment:
Participant gender:
Summary
Some aspirin-treated patients have a blunted pharmacological response predisposing to
clinical failure. The investigators hypothesize that the blunted response often results from
increased rate of platelet production and some failures will be prevented by administering
aspirin twice daily. The overall objective is to develop a valid method to quantify platelet
production (without the use of radioactive isotopes) in order to examine the hypothesis that
enhanced platelet production is a common cause of poor aspirin responsiveness in patients
with atherothrombosis.