Sevoflurane Associated With Oral Midazolam and Ketamine for Dental Sedation
Status:
Completed
Trial end date:
2014-11-01
Target enrollment:
Participant gender:
Summary
There is still extensive debate on the best method of controlling the behavior of preschool
children during dental treatment. Protective stabilization, moderate sedation and general
anesthesia are advanced behavior control techniques indicated for the dental treatment of
early childhood caries and offer advantages and disadvantages during the procedure or
immediately after. Many children with early childhood caries require invasive dental
treatment. According to the final report of a large epidemiological survey on the oral
condition of Brazilians, five-year-old children had an average of 2.43 primary teeth with
caries and fewer than 20% of these had been treated in 2010. This disease also remains a
public health problem in most developed countries; 19.5% of 2-5-year-old American children
have untreated cavities.
There is, however, a lack of the ideal sedative. Such drugs must, on the one hand, control
the behavior of integral form, provide amnesia, minimizing physical discomfort, distress and
pain, and, on the other, safeguard security, with minimal effect on the cardio-respiratory
function, minimizing the occurrence of adverse events, as well as allowing the return of the
patient to a State that allows high safely. The investigators thus performed this prospective
study with the aim to assess the occurrence of adverse events during dental treatment and in
the first 24 hours after sedation with midazolam, ketamine and sevoflurane in children aged
four to six years. Our hypothesis was that no differences in adverse events among different
association of drugs could be found.