Sevoflurane-Remifentanil Interaction: Multiple Response Surfaces, Validation of Calibration Stimuli, Validation of the Intraoperative Isobole Concept and Investigating Remifentanil Induced Opioid Tolerance

• Status: Completed
• Trial end date: 2011-12-01
• Target enrollment: 0
• Participant gender: All

Summary

During this study, the pharmacodynamic interactions between sevoflurane and remifentanil will be studied.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University Hospital, Ghent
• Treatments: Remifentanil; Sevoflurane

Criteria

Inclusion Criteria:

• American Society of Anesthesia class I and II patients

• Aged 18-60 years

• Scheduled for surgery under general anesthesia

Exclusion Criteria:

• Weight less than 70% or more than 130% of ideal body weight

• Neurological disorder

• Diseases involving the cardiovascular system (hypertension, coronary artery disease, prior acute myocardial infarction (AMI), any valvular and/or muscular disease involving decrease of the ejection fraction, arrhythmias, which are either symptomatic or require continuous medication/pacemaker/automatic implantable cardioverter defibrillator [AICD])

• Pulmonary disease including asthma, severe chronic obstructive pulmonary disease (COPD), etc.

• Gastric diseases including reflux, endocrinological diseases

• Recent use of psycho-active medication, including alcohol.