Sevoflurane vs Propofol Effect on Endothelial Damage Markers After Knee Ligament Surgery.

• Status: Completed
• Trial end date: 2019-12-11
• Target enrollment: 0
• Participant gender: All

Summary

Endothelial damage has been reported after ischemia-reperfusion events. This can be characterized by measurements of glycocalyx and endothelial components that are released to blood after the insult. Sevoflurane and inhaled anesthetic commonly used for surgery have shown protective endothelial effects in animal and in-vitro models. Knee-ligament surgery with the use of a femoral tourniquet generates a transient ischemia-reperfusion (IR) state after the tourniquet is released. This research aims to compare the effect of sevoflurane and propofol in the release of glycocalyx and endothelial biomarkers after IR in this surgical scenario.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Chile
• Treatments: Propofol; Sevoflurane

Criteria

Inclusion Criteria:

• American Society of Anesthesiologists Classification (ASA Class) I and II

• Elective knee ligament surgery

• Use of a femoral tourniquet

Exclusion Criteria:

• Allergies to egg or soya

• Previous history of critical events during surgery and perioperative period

• Patients at risk of hyperthermia malignant

• Patients with 3 or more predictor of difficult airway management