Sex Differences, Hormones & Smoking Cessation

• Status: Completed
• Trial end date: 2017-07-27
• Target enrollment: 0
• Participant gender: All

Summary

Data suggest that progesterone may improve smoking cessation outcomes perhaps by reducing impulsive behavior. However, the clinical literature on this topic is lacking. Therefore, in Project I we are proposing a double-blind randomized controlled trial to assess the role of exogenous progesterone on impulsivity and smoking cessation in a sample of males and females who are motivated to quit smoking.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Minnesota; University of Minnesota - Clinical and Translational Science Institute
• Collaborator: National Institute on Drug Abuse (NIDA)
• Treatments: Progesterone

Criteria

Inclusion Criteria:

• Male 18 to 60 years old

• Female 18 to 50 years old

• Self-report regular smoking

• Motivated to quit smoking

• In stable physical/mental health

• Self report of regular menstrual cycles (female only)

• English fluency

• Understand the study procedures and able to provide informed consent

• Ability to participate fully in research elements for the duration of the trial.

Exclusion Criteria:

• Current or recent (< 3 months) breastfeeding (females only)

• Current or planned pregnancy within the next three months (females only)

• Conditions contraindicated to progesterone treatment.