Sex Differences in Sympathetic Vascular Reactivity at High Altitude

• Status: Enrolling by invitation
• Trial end date: 2023-11-01
• Target enrollment: 0
• Participant gender: All

Summary

This study aims to investigate sex differences in blood pressure control associated with exposure to acute hypoxia (low oxygen), and short term acclimatization to hypoxia at high altitude.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Alberta
• Treatments: Nitroprusside; Norepinephrine; Oxymetazoline; Phentolamine; Phenylephrine; Propranolol; Synephrine

Criteria

Inclusion Criteria:

• Between ages of 18-50

• No medical history of cardiovascular, respiratory, nervous system, or metabolic disease

• Females must be pre-menopausal

Exclusion Criteria:

• Any known cardiovascular, respiratory, nervous system, or metabolic disease (however, participants with controlled arterial hypertension will not be excluded)

• Having travelled above 2,000m within 1 month of testing at low and high altitude

• Females who are pregnant, confirmed by a pregnancy test

• Females who are post-menopausal

• Participants that are classified as obese (body mass index > 30kg⋅m²)

• Participants who are current daily smokers

• Those with a known allergy to sulfites

• Participants taking monoamine oxidase (MAO) inhibitors or tricyclic antidepressants or other medications that have contraindications with the study drugs

• Participants who are still within the washout period from participating in other studies involving drugs.