Sex-related Differences in Sympathetic Vascular Transduction in the Setting of Hypoxemia

• Status: Not yet recruiting
• Trial end date: 2023-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this project is to identify sex-related differences in the effect of hypoxia on sympathetic vascular transduction.

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Missouri-Columbia
• Collaborator: American Heart Association
• Treatments: Propranolol

Criteria

Inclusion Criteria:

• healthy adult men and women;

• 18-45 years of age;

• BMI 18-30 kg/m2;

• non-pregnant/non-breastfeeding;

• non-nicotine users;

Exclusion Criteria:

• Pregnancy, breastfeeding, hormonal contraceptives

• Diagnosed sleep apnea

• Current smoking/Nicotine use/drug use

• Nerve/neurologic disease

• Cardiovascular, hepatic, renal, respiratory disease

• Blood pressure ≥140/90 mmHg

• Diabetes, Polycystic ovarian syndrome

• Communication barriers

• Prescription medications

• Recent COVID-19 diagnosis with symptoms