Septic shock is a common and critical illness in ICU.The vascular dysfunction of septic shock
is manifested by vasospasm and decreased arterial vascular reactivity . Current studies have
shown that the main mechanisms of vasospasm and decreased arterial vascular reactivity
include increased vasospasm and down-regulation of receptor sensitivity , and eventually
cause a decrease in vascular smooth muscle contractility.A large number of vasodilators are
released during septic shock, in which inducible nitric oxide synthase (iNOS) and
prostacyclin (PGI2) are important vasodilators leading to septic shock vasospasm.At present,
vasoactive drugs are widely used in clinically to improve vascular tone and are important
means of circulation support. However, when the infection is heavier, the reactivity of the
blood vessels to the vasoactive drugs is lowered, and it is difficult for the large doses of
the vasoactive drugs to maintain the circulation stability. At this time, the use of
vasoactive drugs alone does not benefit patients with septic shock and may require the
combination of other drugs.From the perspective of Chinese medicine, shock is a disease of
yang. Shenfu injection has the effect of rejuvenating the yang and replenishing the qi. This
trial was designed to give patients with septic shock the use of Shenfu injection to
determine the specific effects of Shenfu injection on vascular reactivity in patients with
septic shock.