Short (5 Days) Versus Long (14 Days) Duration of Antimicrobial Therapy for Acute Bacterial Sinusitis in Children

• Status: Completed
• Trial end date: 2016-02-01
• Target enrollment: 0
• Participant gender: All

Summary

The investigators objective is to compare short course (5 days) to long course (14 days)antibiotics for the treatment of acute bacterial sinusitis in children. The investigators hypothesize that short course therapy will lead to more frequent relapses of sinusitis and will not reduce resistant organisms.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Wisconsin, Madison
• Collaborator: Thrasher Research Fund
• Treatments: Amoxicillin; Amoxicillin-Potassium Clavulanate Combination; Anti-Infective Agents; Clavulanic Acid; Clavulanic Acids

Criteria

Inclusion Criteria:

1. children with nasal discharge (of any quality) or daytime cough (which may be worse at night) or both persisting for 10 days or more without evidence of improvement.

2. families need to be English speaking

Exclusion Criteria:

1. used antibiotics within the last 15 days;

2. had symptoms for > 30 days;

3. have concurrent streptococcal pharyngitis or acute otitis media (as the standard doses for both of these conditions is 10 days);

4. are allergic to penicillin;

5. have symptoms that suggest a complication due to acute bacterial sinusitis that necessitates hospitalization, intravenous antibiotics or sub-specialty evaluation

6. been diagnosed with either immunodeficiency or anatomic abnormality of the upper respiratory tract

7. history of recurrent acute sinusitis (more than 3 episodes in 6 months or 4 episodes in a year)

8. history of chronic sinusitis (more than 90 days of respiratory symptoms in this or the previous respiratory season)

9. girls who have begun menstruating