Short-Course Isoniazid and Rifampin Compared With Isoniazid for Latent Tuberculosis Infection
Status:
Terminated
Trial end date:
2006-02-01
Target enrollment:
Participant gender:
Summary
The objective of the study was to compare the compliance and the side effects of a short
course to treatment of latent tuberculosis infection during 3 months(isoniazid plus
rifampin)group I, with the standard course for 6 months(isoniazid)group II .Prospective,
comparative, randomized and open trial of patients with positive TST and the suitable
criteria for treatment, in accordance with the guidelines of the CDC, excluding HIV
infection. 105 patients were included. In Conclusion, a short course with isoniazid plus
rifampin during 3 months shown better compliance with a lower percentage of abandonment that
the course 6H. Tolerance is similar in the two courses.