Short Life Agents in Balanced Anesthesia on Obstructive Sleep Apnea Syndrome

• Status: Completed
• Trial end date: 2018-06-01
• Target enrollment: 0
• Participant gender: All

Summary

The investigators aim to assess the respiratory effect of short half-life agents in balanced anesthesia on patients suffering from non-treated or suspected obstructive sleep apnea syndrome (OSA) We will study the impact on OSA of a regimen of remifentanil-desflurane versus a regimen of fentanyl-sevoflurane. Each patient will undergo three respiratory portable polygraphies: the night before the surgery ; the first night following the surgery ; the third night following the surgery.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Centre Hospitalier Universitaire Vaudois
• Treatments: Anesthetics; Desflurane; Fentanyl; Remifentanil; Sevoflurane

Criteria

Inclusion Criteria:

• Physical status I - III

• Patient scheduled to undergo lower limb orthopedic surgery

• Patients known for non-treated obstructive sleep apnea or suspected of having an obstructive sleep apnea

Exclusion Criteria:

• Patients known for treated obstructive sleep apnea ;

• Severe respiratory disease (i.e., chronic obstructive pulmonary disease, asthma, pulmonary fibrosis);

• Severe cardiovascular disease

• Chronic use of opiates ≥ 30mg/j morphine eq.

• Chronic use of benzodiazepine

• Inability to consent

• Refusal