The research aims to provide data on gender-related psychological impact of GH (Growth
Hormone)treatment. Implicit measurable psychological metrics of the therapy outcome on males
are to be evaluated in a Prospective Randomized Controlled Trial. As a secondary axis of the
study, the investigators aim to provide descriptive documentation of the unique distress
signal manifestation implicitly shown by Idiopathic Short Stature (ISS) boys and suggest
methods of early detection and measurement of such manifestations that can be used to cement
guidelines for the treatment in GH.