Short-Term Intensive Insulin Therapy Induction of Long-term Glycemic Control

• Status: Completed
• Trial end date: 2011-12-01
• Target enrollment: 0
• Participant gender: All

Summary

We designed this prospective, randomized control study to compare the benefits between the insulin therapy and OADs after correction of the glucose toxicity with a short period of intensive insulin therapy.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Taipei Veterans General Hospital, Taiwan
• Treatments: Gliclazide; Insulin; Insulin, Globin Zinc; Isophane Insulin, Human

Criteria

Inclusion Criteria:

1. Newly diagnosed type 2 diabetic patients.

2. Hospitalization due to hyperglycemia hyperosmolality syndrome.

3. Those who age between 30 and 80 years old and can inject insulin by themselves.

Exclusion Criteria:

1. Pregnant women.

2. Impaired liver function (ALT > 120 U/L)

3. Impaired renal function (Serum creatinine >3.0 mg/dL)

4. Recently suffered from MI or CVA.

5. Patients are acute intercurrent illness.

6. 2-hour C-peptide level < 1.8 ng/mL.