Short Term Spironolactone for Prevention of Acute Kidney Injury After Cardiac Surgery

• Status: Unknown status
• Trial end date: 2015-07-01
• Target enrollment: 0
• Participant gender: All

Summary

Our aim is to test whether short term perioperative administration of oral spironolactone could reduce incidence of postoperative acute kidney injury (AKI) in cardiac surgical patients.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Instituto Nacional de Cardiologia Ignacio Chavez
• Collaborator: Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
• Treatments: Spironolactone

Criteria

Inclusion Criteria:

• Informed consent

• Elective and emergent cardiac surgery with cardiopulmonary bypass and aortic cross clamp

Exclusion Criteria:

• Patients with preoperative chronic renal insufficiency on dialysis

• Acute kidney injury detected up to 24 hours before the procedure a

• Patients receiving contrast agents 72 hours before surgery

• Planned off-pump cardiac surgery

• Hypersensitivity, allergy or known intolerance to spironolactone

• Pregnancy

• Hyperkalemia with potassium >5.0 mEq/L

Criteria for stopping study medication:

• Serum potassium >5.5 mEq/L