Short-term Effect of Extended-release Niacin on Endothelial Function.

• Status: Completed
• Trial end date: 2013-06-01
• Target enrollment: 0
• Participant gender: All

Summary

Individuals with reduced plasma concentration of high-density lipoprotein (HDL) cholesterol are more susceptible to oxidative stress and often present reduced endothelial function, which has been mainly related to this susceptibility. Studies in animal and cell models have demonstrated that niacin activates both GPR-109A in leukocytes and heme oxygenase-1 (HO-1) pathway promoting strong anti-inflammatory and anti-oxidative effects. . In this context, the aim of this study was to investigate the short-term effect of niacin on endothelial function and verify the existence of interaction of PGD2 receptor antagonist, i.e. laropiprant (LRPT), in subjects with low HDL-cholesterol (HDL -C).

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Campinas, Brazil
• Treatments: Niacin; Niacinamide; Nicotinic Acids

Criteria

Inclusion Criteria:

• asymptomatic individuals

• plasma HDL-C levels <40 mg/dL

Exclusion Criteria:

• symptomatic atherosclerotic disease

• diabetes

• liver disease

• renal disease

• thyroid dysfunction

• indication for or use of lipid-lowering treatment in the last six months

• use of anti-inflammatory treatment in the last 30 days

• current or previous diagnosis of cancer or immune inflammatory diseases

• chronic obstructive pulmonary disease

• infectious disease manifested in the last 3 months

• body mass index ≥ 26 kg/m2