Short-term Effects of Perindopril-amlodipine Versus Perindopril-indapamide in Type 2 Diabetes

• Status: Completed
• Trial end date: 2017-05-30
• Target enrollment: 0
• Participant gender: All

Summary

This was a double-blinded randomized controlled trial of 24-hour blood pressure control in sub Saharan type 2 diabetes patients, newly diagnosed for hypertension. They were allocated to receive either a fixed combination of perindopril + amlodipine or perindopril + indapamide for 42 days.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Yaounde Central Hospital
• Collaborator: University of Yaounde 1
• Treatments: Amlodipine; Indapamide; Indapamide, perindopril drug combination; Perindopril

Criteria

Inclusion Criteria:

• adult diabetes patients aged between 25-65 years,

• with grade I or grade II (WHO classification) hypertension on the clinical measure, confirmed by ABPM

• naïve to any anti-hypertensive treatment

• written informed consent.

Exclusion Criteria:

• Patients with grade III hypertension (WHO classification) were classified as hypertensive emergency,

• estimated creatinine clearance ˂30ml/min/1.73m2 (using Modified Diet in Renal Diseases formula)

• alanine transaminase (ALT)≥ 3 normal

• any contraindication to study drugs (hypersensitivity)

• pregnant or breastfeeding women