Short-term Steroid for Acute Tinnitus Therapy

• Status: Recruiting
• Trial end date: 2023-07-01
• Target enrollment: 0
• Participant gender: All

Summary

The goal of this clinical trial is to learn about the efficacy of oral steroids in the acute tinnitus population. The main question it aims to answer is whether oral prednisone intervenes with acute tinnitus as early as possible. Participants will receive appropriate dosages of prednisone and/or oral Ginkgo Biloba tablets.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Eye & ENT Hospital of Fudan University
• Treatments: Prednisone

Criteria

Inclusion Criteria:

1. 18-65 years old;

2. primary complaint of non-pulsatile tinnitus ≤ 3 months of duration;

3. a decline in auditory function by audiological assessments on the day of the test, of which the outcome must either satisfy one of the following conditions:

1. a reduced distortion product otoacoustic emissions (DPOAE) amplitude in individuals with normal Pure tone audiometry (PTA) results;

2. more than a PTA threshold > 25 dB with frequencies between 125 and 8000 Hz, but not exhibited idiopathic sudden sensorineural hearing loss;

4. a state of good general condition;

5. with good adherence to participation and signed informed consent.

Exclusion Criteria:

1. history of other obvious causes of tinnitus (such as otitis media, tympanic membrane perforation, external auditory canal inflammation);

2. physical trauma to the ear immediately preceding tinnitus;

3. both the PTA and DPOAE with normal outcomes;

4. history of known corticosteroids contraindications (including osteoporosis, peptic ulcers, poorly controlled hypertension, diabetes, chronic liver or renal insufficiency, tumorous condition, alcohol abuse, pregnant patients, and women on estrogen-containing oral contraceptive steroids).